Brontekst bekijken van uz:V1.0.0-alpha.1 FHIR OBC

{{Vdraft/InformationBox|This FHIR IG is currently under development and can not be considered stable and ready for use. For questions and change requests regarding this IG, please create a ticket in [{{VersieInfo|BITS|release=V1.0.0-alpha.1|namespace=uz}} BITS].}}

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{{DISPLAYTITLE:FHIR Implementation Guide OBC version {{VersieInfo|OBC|release=V1.0.0-alpha.1|namespace=uz}}}}

= Introduction =

This implementation guide (IG) functions as the initial draft for the pilot phase of a new information standard, Outcome-Based Care (OBC, Dutch: Uitkomstgerichte zorg), version {{VersieInfo|OBC|release=V1.0.0-alpha.1}}. This IG is developed using [https://www.hl7.org/fhir/R4/ HL7 FHIR R4]. It assumes that the reader is familiar with both this version of FHIR and the functional specification [TO-ADD link]. This information standard is inspired by the international [http://hl7.org/fhir/us/sdc/index.html Structured Data Capture (SDC)] implementation guide and tries to follow it where possible.

Apart from this document, the guidelines as specified in the [[FHIR:V1.0.0-alpha.1_FHIR_IG_R4|general FHIR Implementation Guide]] apply. In particular, the reader should take note of the Overarching principles and the use of FHIR packages. 

This IG first describes the boundaries and relationships in place, after which the implementation of PROMs in FHIR is described.

= Boundaries and relationships =

== Boundaries ==
As mentioned in the introduction, this IG serves as a precursor for the pilot phase of the new information standard OBC. This version of the IG focuses solely on the manifestation of PROM questionnaires and their corresponding answers in FHIR. It does not include clinical data or use cases for data exchange, as the primary goal of the pilot is to evaluate the feasibility of implementing FHIR in this context. It is the intention to expand the scope in future versions of the IG to include clinical data and data exchange use cases, ultimately aiming to develop OBC into a comprehensive information standard.

== FHIR resources and building blocks ==
The PROM questionnaires and response data building blocks within OBC version {{VersieInfo|OBC|release=V1.0.0-alpha.1}} are not based on any publication of the Dutch Health and Care Information Models (Dutch: "zorginformatiebouwstenen" or "zibs"), as there are no zibs that represent these building blocks. Therefore, there is no dependency on corresponding nl-core profiles, and mappings to zib concepts are not defined. Currently, there are no plans to create more general nl-core profiles, as no corresponding zibs exist. 

=== Questionnaire ===

Each PROM questionnaire is represented through a dedicated FHIR Questionnaire instance. A FHIR Questionnaire is a definitional artifact, which means it defines the questions to be asked, how these should be structured and rendered, and what answers are allowed. More information on structure and rendering of the FHIR Questionnaire instances can be found in [[#Rendering|section 2.4]]. The answer options to each question are represented through terminology resources using ValueSets and CodeSystems.

The Questionnaire resource isn't strictly necessary to create a QuestionnaireResponse. However, using FHIR Questionnaire instances for PROMs provides significant benefits through standardized and structured formatting. Each question is included in the Questionnaire as a separate {{fhir|.item}} and has a unique identifier in the corresponding {{fhir|.item.linkId}} element. Additionally, the terminology used in PROMs is represented in FHIR ValueSet and CodeSystem resources and is correctly linked to the questions in the Questionnaire, ensuring all definitions are easily accessible for implementers.

=== QuestionnaireResponse ===

The collection of outcomes and scores of a PROM is represented in a FHIR QuestionnaireResponse profile. For every completed PROM, an instance conforming to the [https://simplifier.net/nictiz-r4-outcomebasedcare/obcresponsedata obc-ResponseData] profile is created. This profile features a structured set of answers with linked ids to the answered questions. The QuestionnaireResponse also includes the completion date and the language of the completed form.

The QuestionnaireResponse contains enough information about the questions asked that it can be interpreted somewhat independently from the Questionnaire it is based on. In other words, no access to the Questionnaire is necessary in order to extract basic information from a QuestionnaireResponse.

=== Main building blocks ===

{| class="wikitable"
! style="font-weight: bold;text-align:left;" | Building block (EN)
! style="font-weight: bold;text-align:left;" | Building block (NL)
! style="font-weight: bold;text-align:left;" | FHIR resource
! style="font-weight: bold;text-align:left;" | FHIR profile
|-
| ResponseData
| Antwoordgegevens
| QuestionnaireResponse
| {{Simplifier|http://nictiz.nl/fhir/StructureDefinition/obc-ResponseData|nictiz.fhir.nl.r4.obc|pkgVersion={{VersieInfo|nictiz.fhir.nl.r4.obc|release=V1.0.0-alpha.1|namespace=obc}}}}
|}

Note that each PROM questionnaire building block in the functional data set is represented by a separate Questionnaire instance. However, these are not listed here, but are instead added as [https://simplifier.net/nictiz-r4-outcomebasedcare//~resources?category=Example&exampletype=Questionnaire MISSING instances] to the FHIR package.

== Mappings between profiles and data set ==
=== Questionnaire instances ===

Each FHIR Questionnaire instance includes specific elements that correspond to functional definitions in the ART-DECOR dataset. This dataset offers a concise overview of the content and structure of each questionnaire. The actual mapping of FHIR elements to these functional definitions occurs at the [https://docs.art-decor.org/documentation/ "Scenario" and "Rules"] levels within ART-DECOR. However, the following table presents the dataset's structure, independent of the mappings to the "Scenario" and "Rules" levels:

{| class="wikitable"
! style="font-weight: bold;text-align:left;" | Concept in Dataset
! style="font-weight: bold;text-align:left;" | Mapping
! style="font-weight: bold;text-align:left;" | Type
! style="font-weight: bold;text-align:left;" | Remark
|-
| '''Metadata'''
| 
|
|
|-
| &nbsp;&nbsp;&nbsp;&nbsp;Vragenlijstcode
| Questionnaire.code
| string 
|
|-
| &nbsp;&nbsp;&nbsp;&nbsp;Naam vragenlijst
| Questionnaire.title
| string
|
|-
| &nbsp;&nbsp;&nbsp;&nbsp;Eigenaar/Uitgever
| Questionnaire.copyright
| string
|
|-
| &nbsp;&nbsp;&nbsp;&nbsp;Versie
| Questionnaire.version
| string
|
|-
| &nbsp;&nbsp;&nbsp;&nbsp;Taal
| Questionnaire.meta.language
| code
|
|-
| &nbsp;&nbsp;&nbsp;&nbsp;Domein
| Questionnaire.useContext.valueCodeableConcept
| coding
| Questionnaire.useContext.code must be populated with the code [https://hl7.org/fhir/r4/codesystem-usage-context-type.html#usage-context-type-focus ''focus'']
|-
| &nbsp;&nbsp;&nbsp;&nbsp;Licentie-informatie
| Questionnaire.copyright
| markdown (string)
|
|-
| '''Content Questionnaire'''
| 
|
|
|-
| &nbsp;&nbsp;&nbsp;&nbsp;Instructie
| Questionnaire.item.text
| string
| Questionnaire.item.readOnly must be set to ''true''
|-
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Question
| Questionnaire.item.text
| string
|
|-
| &nbsp;&nbsp;&nbsp;&nbsp;Totaalscore
| Questionnaire.item.text
| string
| [https://hl7.org/fhir/R4/extension-questionnaire-hidden.html Questionnaire.item.extension:hidden] must be set to ''true''
|-
| '''Rekenregels'''
| 
|
|
|-
| &nbsp;&nbsp;&nbsp;&nbsp;Scorerichting item
| Questionnaire.item
| string
| [https://hl7.org/fhir/R4/extension-questionnaire-hidden.html Questionnaire.item.extension:hidden] must be set to ''true''
|-
| &nbsp;&nbsp;&nbsp;&nbsp;Scoreberekening
| Questionnaire.item
| string
| [https://hl7.org/fhir/R4/extension-questionnaire-hidden.html Questionnaire.item.extension:hidden] must be set to ''true''
|-
| &nbsp;&nbsp;&nbsp;&nbsp;Interpretatie score
| Questionnaire.item
| string
| [https://hl7.org/fhir/R4/extension-questionnaire-hidden.html Questionnaire.item.extension:hidden] must be set to ''true''
|-
|}
Additionally, instances include concepts that are not directly represented in the dataset, such as formatting. Instead, these concepts are found within the "Rules" level in ART-DECOR:
{| class="wikitable"
! style="font-weight: bold;text-align:left;" | Concept in Rules
! style="font-weight: bold;text-align:left;" | Mapping
! style="font-weight: bold;text-align:left;" | Type
|-
| Canonical URI
| Questionnaire.url
| uri
|-
| '''Content Questionnaire'''
| 
|
|-
| &nbsp;&nbsp;&nbsp;&nbsp;Instructie
| [http://hl7.org/fhir/R4/extension-rendering-style.html ??Questionnaire.item.extension:renderingStyle]
| string
|-
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Question
| [https://build.fhir.org/ig/HL7/fhir-security-label-ds4p/StructureDefinition-extension-inline-sec-label.html Questionnaire.item.extension:sensitivityFlag]
| coding
|-
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Question
| [http://hl7.org/fhir/R4/extension-rendering-style.html ??Questionnaire.item.extension:renderingStyle]
| string
|}
* For this project, it has been agreed to map all functional data elements to the operationalization fields in ART-DECOR.
* The publisher concept is mapped to {{fhir|.publisher}}. This concept is consistent across the project and remains unchanged for all Questionnaire instances.
* The concept of "Eigenaar/Uitgever" (English: Author/Publisher) is mapped to {{fhir|.copyright}}. This is because the concept encompasses author information, which lacks a dedicated field in the Questionnaire resource. {{fhir|.copyright}} addresses both author and license information for this project.
* For this pilot, "Content Questionnaire" includes the following content folders: Content NRS-pijn intensiteit, Content FACIT-F, IBD-control, Content Depressie SF 4a, and Content Global Health-10.
* The "Question" refers to each individual element within the Instructie folder.
* The "Instructie" data (English: Instruction) has been set to read-only, because it is intended for users to read, not to respond to. The "Rekenregels" data (English: Calculation rules) is hidden from users, as it is used for calculations, comparing results, and providing context on the scores.

=== QuestionnaireResponse profile ===
The QuestionnaireResponse profile is connected to the functional definitions in ART-DECOR. It includes mappings to all data elements within the functional data set (prefixed with "obc-dataelement-10-").

Each profile (implicitly; this will be explicitly added in a subsequent version) contains a Patient building block with cardinality 1..1 M. This patient is the subject of the PROM questionnaire, and is referenced from the ResponseData building block. Therefore, a reference to a Patient resource conforming to the nl-core-Patient profile is expected in {{fhir|QuestionnaireResponse.subject}}.

== Questionnaire URL ==

The primary purpose of representing PROMs as Questionnaire instances is to establish a canonical identifier for each PROM in the form of a URI. This URI serves as a linkage point connecting every QuestionnaireResponse to their corresponding Questionnaire. A Questionnaire is referenced by other resources using its canonical URL, which is composed of a base URL followed by a UID generated by ART-DECOR: <pre>http://decor.nictiz.nl/fhir/Questionnaire/2.16.840.8.113882.1.2.3.44.60.140.27.9--12345673145430</pre>

== Questionnaire versioning ==
PROMs are subject to change over time, with alterations or additions made to their questions and answer options, as well as to the underlying algorithm used to calculate the scores. Any changes made to these PROMs are recorded and disseminated through ?Amigo?. Since PROMs might develop through time, it is crucial to determine which version of the PROM was filled out by the subject.

In FHIR, the version of a PROM can be registered in the {{fhir|Questionnaire.version}} element. A Questionnaire is referenced in a QuestionnaireResponse (and possibly other resources) by its [https://www.hl7.org/fhir/r4/references.html#canonical canonical URL]. To reference a particular version of a Questionnaire, users must combine the canonical URL and version using a pipe character in the format: [canonicalURL]|[version]. When users refer to a Questionnaire with just the {{fhir|.url}}, they automatically refer to the latest version.

However, the definition of "latest version" may vary for Amigo compared to what the PROMs provider may consider latest. Therefore, to ensure clarity about which version of the PROM is requested and collected, any references in the {{fhir|QuestionnaireResponse.questionnaire}} SHALL always include a specific version.

To note:
*The assumption is that all PROMs will be registered with a version number.
*Questionnaire authors will be responsible for assigning version numbers to maintain a consistent standard across the organization. Amigo will ensure that these versions are kept up to date.

== Rendering ==
A PROM questionnaire may take the form of a straightforward flat list of questions, but may also be hierarchically organized in groups and subgroups including patient instructions. Likewise, it can contain a wide range of question types, varying from simple fill-out fields to multiple-choice questions, scales and questions with dependencies to previous answers. As a result, it might be necessary to render items in a questionnaire.

The FHIR base Questionnaire resource offers limited rendering capabilities, with item labels and text elements displayed sequentially, and choice options provided through renderer-determined controls. For more control, the core specification defines additional elements and extensions, including the [http://hl7.org/fhir/R4/extension-rendering-markdown.html rendering-markdown] extension, which leverages [https://github.github.com/gfm/ GitHub Flavored Markdown (GFM)] for text formatting, like adding emphasis. While systems aren't required to support markdown, strings should remain readable without markdown processing.

The JSON snippet below provides an example of a Questionnaire instance that uses the rendering-markdown extension to emphasize part of an item.

[INSERT SNIPPET]

== Sensitive questions ==

Every PROM may include sensitive questions, indicating that the answers might contain sensitive information. As a result, a specific level of authorization is required to read these answers.

The [http://hl7.org/fhir/uv/security-label-ds4p/ Data Segmentation for Privacy project] defined the [https://build.fhir.org/ig/HL7/fhir-security-label-ds4p/StructureDefinition-extension-inline-sec-label.html Inline Security Label extension]. This extension enables flagging elements with a security label, for example indicating their sensitivity, and SHALL be added to all relevant {{fhir|.item}} elements as {{fhir|.item.extension:sensitivityFlag}} in both the Questionnaire and QuestionnaireResponse instances. The {{fhir|.valueCoding}} SHALL be populated with the code ''PDS'' from the [http://hl7.org/fhir/R4/v3/InformationSensitivityPolicy/vs.html InformationSensitivityPolicy ValueSet] to indicate this data item contains sensitive information reported by the patient.

== Scores and calculation rules ==
The Questionnaire definition includes information on how to calculate the total score, the weight for each question, and how to interpret the total score. Currently, this information is provided in {{fhir|.item}} elements, where the calculation rules are read-only instructions and hidden from users completing the forms through an extension.

In the next version of the Questionnaire definition, it is the intention to incorporate dynamic calculation rules using structured data capture, making the Questionnaire more structured and flexible.